The Endocrine Role of Adipose Tissue and Its Management of Obesity-Related Diseases
1 ; 1 ; in Month : September (2020) Article No : semrj-v1-1004
Adipose tissue plays a central role in regulating whole-body energy. Moreover, adipose tissue acts as an endocrine organ and produces numerous bioactive factors called adipokines which communicate with other organs and modulate a range of metabolic pathways: proteins (adiponectin, angiopoietins, chemerin, etc.), lipids (fatty acid esters of hydroxyl fatty acids, lysophosphatidic acids and sphingolipids), metabolites (uric acid and uridine) and microRNAs. However, excessive adipose tissue is associated with a chronic state of low-grade inflammation, caused by unbalanced production or secretion of these adipokines and can contribute to the development of obesity . According to the World Health Organization, the global prevalence of obesity has nearly tripled since 1975 and in 2016, more than 1.9 billion adults, 18 years and older, were overweight. Of those over 650 million were obese . An understanding of the mechanism underlying the metabolic actions of adipokines is fundamental for the development of novel therapeutics for obesity. Obesity has become the largest epidemic globally.
• A few adipokines are reduced in individuals with obesity.
• Anti-obesity treatments promote weight loss with side effects.
• Adiponectin can promote beneficial effects on obesity-related diseases.
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